食管钡餐连续摄影用于诊断早期食管癌的初步临床应用

目的 :介绍食管钡餐连续摄影用于诊断早期食管癌的初步临床应用。方法 :用德国产的数字化胃肠机检查并诊断了 6例早期食管癌病人。与常规食管双重对比造影类似 ,病人立位口服钡剂 ,同时进行连续摄影 ,速度为 2帧 s,持续约 10s。观察不同的时相 ,包括充盈相、黏膜相和双对比相。结果 :在 6例病人中可见食管功能的改变及黏膜皱襞的病变 ,用连续摄影诊断后经内镜及病理检查确诊。 4例病人有轻度扩张受限 ,2例病人有痉挛性收缩 ,1例有钡剂滞留。 6例病人中均可见增粗的或中断的黏膜。 5例病人可见小溃疡。结论 :食管钡餐连续摄影可提供更全面的信息。用此法更可提供食管功能性的改变。     

Significance of beaten copper appearance on skull radiographs in children with isolated sagittal synostosis

Aims and Objectives The significance of beaten copper appearance (BCA) on skull radiographs in children following surgery for isolated sagittal craniosynostosis has not been studied. This study was designed to look for any correlation between BCA and symptoms suggestive of intracranial hypertension in this group of patients. Materials and Methods Forty-eight consecutive children, who were operated for isolated sagittal synostosis from1987 to 2000 and had postoperative skull radiographs, were included. Patients were divided into: (a) BCA group (n = 20), consisting of children who had beaten copper appearance on skull radiographs at last follow up, and (b) Non-BCA group (n = 28), consisting of children who did not have this finding. Records were reviewed to look for symptoms suggestive of intracranial hypertension, such as headache, head banging, and irritability. Results Median age at surgery was 4.8 months for BCA group and 4 months for the non-BCA group. Follow up ranged from 4 to 156 months with a mean of 36.2 months. Total of 28.6% (n = 6) of the children with follow up radiographs done at ≤18 months of age had BCA. The incidence of BCA increased to 83.3% in children with skull radiographs performed after 48 months of age. In 18 (90%) children, the BCA was ‘diffuse’ with 5 (25%) children having the maximum possible score of 8. In the BCA group, 45% (n = 9) had symptoms compared to 10.7% (n = 3) in the control group (p = 0.0068). Conclusions This study suggests a significant number of children with BCA on radiographs develop symptoms suggestive of raised ICP following surgical treatment in infancy and prolonged follow up may be warranted in this group of patients.     

粗糙脉孢菌漆酶基因的克隆及在毕赤酵母中的初步表达

采用连续延伸PCR方法克隆到粗糙脉孢菌（Neurospora crassa）漆酶基因，并将其克隆到表达载体pPIC9k，重组质粒经线性化、电激转化Pichia pastoris KM71，部分阳性克隆的PCR结果表明：漆酶基因已整合到巴斯德毕赤酵母染色体上，重组菌经甲醇诱导后3～5d产漆酶量最高，为2-3U／mL。     

试论医院药剂科的法律地位和作用

本文论述了医院药剂科的法律地位和作用,药政部门的执法盲点,提出法律措施是促使医药同步发展的可靠保障。     

Parenchymal and pleural fibrosis in construction workers.

Exposure to mineral dust was studied among construction workers (N = 437) with the aid of a questionnaire and a chest X-ray examination of the lungs. The results of the questionnaire showed that 81% of the construction workers had been exposed to asbestos. Exposure had occurred in all of the occupational groups studied. Pleural plaques and/or lung fibrosis (ILO greater than or equal to 1/1) were found in 26% of the examined workers; the prevalence varied from 18 to 40% among the various occupational groups. Comparison with a representative sample of the Finnish male population from another investigation indicates that the frequency of lung fibrosis (ILO greater than or equal to 1/1) is at least two times higher among the examined construction workers than among the general population. It seems likely that exposure to asbestos dust can be considered an etiological factor for an appreciable number of the X-ray findings.     

准分子激光角膜原位磨镶术治疗近视合并中度以上散光疗效观察

目的 :评价小光斑飞点扫描准分子激光系统应用于准分子激光原位角膜磨镶术 (LASIK)治疗近视合并中度以上散光的疗效。　方法 :对 96例患者 14 4只眼按术前屈光度分成三组 ,Ⅰ组 75只眼 ,近视 0～ - 6D ,散光 - 2～ - 4DC ;Ⅱ组 5 7只眼 ,近视 - 6 .2 5～ 10 .0 0D ,散光 - 2～ - 4DC。Ⅲ组 12只眼 ,近视 - 10 .2 5D以上 ,散光 - 2～- 4DC ;术后随访半年以上 ,并将结果进行比较分析。　结果 :术后 1个月裸眼视力达到 0 .6以上者 ,Ⅰ组为5 .3% ,Ⅱ组为 15 .8% ,Ⅲ组为 6 6 .7% ;术后 1个月裸眼视力达到 1.0以上者 ,Ⅰ组为 94 .7% ,Ⅱ组为 84 .2 % ,Ⅲ组为 33.3%。术后半年裸眼视力达到 0 .6以上者 ,Ⅰ组为 4 % ,Ⅱ组为 14 % ,Ⅲ组为 75 % ;术后半年裸眼视力达到 1.0以上者 ,Ⅰ组为 96 % ,Ⅱ组为 86 % ,Ⅲ组为 2 5 %。术后屈光度在± 1.0D以内者 ,Ⅰ组中为 8% ,Ⅱ组为 14 % ,Ⅲ组为 5 8.3%。术后屈光度在± 0 .5 0D以内者 ,Ⅰ组为 92 % ,Ⅱ组为 86 % ,Ⅲ组为 4 1.7%。术后散光度在± 1.0DC以内者 ,Ⅰ组为 8% ,Ⅱ组为 10 .5 % ,Ⅲ组为 5 0 %。术后散光度在± 0 .5 0DC以内者 ,Ⅰ组为 92 % ,Ⅱ组为 89.5 % ,Ⅲ组为 5 0 %。平均实际切削区直径为 (8.0 2± 0 .0 6 9)mm。　结论 :使用小光斑飞点显像LASIK治疗低     

Extensive Aberrant Mongolian Spot

A 9-month-old male infant had generalized diffuse blue-gray pigmentation over most of his body, sparing the scalp, face, neck, palms, soles, periumbilical area, genital area, and nipples. Within the lesion, there were several conspicuous macules of considerably darker hue. Histologic examination revealed numerous dermal melanocytes. By 16 months of age, the child's blue-gray pigmentation had decreased substantially.     

应用荧光斑点法和比值法检测G6PD

目的建立适合于G6PD缺乏的新生儿筛查及确诊方法。方法应用荧光斑点法(FST)对新生儿筛查滤纸干血片进行检测，对可疑阳性者召回，抽静脉血以D6PD／6PGD比值法进行确诊，同时结合新生儿父母亲的G6PD结果，根据遗传关系综合分析。结果FST筛查25000例新生儿，G6PD缺乏阳性率为4．56％，确诊检出率为4．09％。与比值法的符合率为90．4％，G6PD重度缺乏者的符合率为100％，G6PD中间缺乏者的符合率为78．5％，室间质量控制结果与反馈结果符合率为100％。结论FST汀具有高的敏感性、特异性和准确性，方法简便、快捷、费用低廉，可对滤纸干血片标本进行大规模的筛查检测，同时利用比值法进行确诊，可减少假阳性及假阴性，有利于早期诊断和防治G6PD缺乏所致的新生儿黄疸和急性溶血。     

汕头市礐石风景区及其周边地区蚊虫种类及生境调查（Diptera：Culicidae）

对汕头市主要旅游景点     

Filter properties of root mean square successive difference (RMSSD) for heart rate

The root mean square successive difference (RMSSD) in heart period series is a time domain measure of heart period variability. The RMSSD is sensitive to high-frequency heart period fluctuations in the respiratory frequency range and has been used as an index of vagal cardiac control. By transfer function simulations, the RMSSD statistic is shown to represent a high-pass filter that effectively captures respiratory sinus arrhythmia but also passes lower frequency fluctuations that can include sympathetic influences. These simulations, together with analysis of actual heart period series, reveal that the RMSSD is biased by basal heart period. Although between-subjects levels of RMSSD covary highly with spectral estimates of high-frequency variability, within-subject RMSSD change scores account for only 50-60% of the variance in spectral estimates. The present findings raise caveats in the applications and interpretation of the RMSSD statistic.